Trial Purpose

The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with haematological malignancies of chronic lymphocytic leukaemia (CLL)/ small lymphocytic lymphoma (SLL), Richter’s transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström’s macroglobulinemia (WM).

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When speaking to your doctor, please have the trial identifier number available.

About The Study

All patients who enroll in the trial will receive medication while on the study.

100% will receive nemtabrutinib

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Phase 2

Tests the medicine or vaccine in approximately 100 to 500 volunteers. In the case of medicines, volunteers usually have the disease or condition the investigational medicine is designed to treat. In vaccine studies, the volunteers are usually healthy.

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  • Actual study start date 5 April 2021
  • Estimated primary completion date 19 March 2027
  • Estimated study completion date 19 March 2027


Only a qualified healthcare professional can determine your eligibility. However, this information may be useful in starting a conversation with your doctor.

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Haematological Malignancies

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Age Range

18 - No Age Maximum

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Trial locations

Locations provided may not reflect the most current site information. Please call the number provided in the location results to confirm.