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Study Keyword: Programmed Cell Death Ligand 1

O objetivo deste estudo é avaliar a segurança e a eficácia de pembrolizumabe mais quimioterapia padrão (SOC) (etoposídeo/platina [EP]) em participantes com câncer de pulmão de pequenas células em estágio extensivo (CPPC-EE) recém-diagnosticado que não receberam anteriormente terapia sistêmica para esta malignidade.

As hipóteses primárias deste estudo são de que pembrolizumabe + EP prolonga a sobrevida livre de progressão (SLP) de acordo com os critérios de avaliação de resposta em tumores sólidos versão 1.1 (RECIST 1.1), com base na revisão central independente em caráter cego (BICR) e a sobrevida global (SG), comparado com placebo + EP em participantes adultos com CPPC-EE. Neste estudo, o RECIST 1.1 foi modificado para acompanhar um máximo de 10 lesões alvo e um máximo de 5 lesões alvo por órgão.

Com a Emenda 07 ao protocolo (03-out-2018), a medida de resultado da “Alteração em relação à avaliação inicial nas Semanas 12 e 24 na Escala de Estado de Saúde Global/Qualidade de Vida do questionário de qualidade de vida Core 30 (QLQ-C30) da Organização Europeia para Pesquisa e Tratamento do Câncer (EORTC)” foi substituída por uma única análise de ponto de tempo na Semana 18.

Study Keyword: Programmed Cell Death Ligand 1

Estudo de pembrolizumabe em combinação com etoposídeo/platina para participantes com câncer de pulmão de pequenas células em estágio extenso

April 22, 2022

By clique_admin

The purpose of this study is to assess the safety and efficacy of pembrolizumab plus standard of care (SOC) chemotherapy (etoposide/platinum [EP]) in participants with newly diagnosed extensive stage small cell

Substudy 02D: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Melanoma Brain Metastasis

March 10, 2022

By Support_Clique

Substudy 02D is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line Renal Cell Carcinoma

March 10, 2022

By Support_Clique

Substudy 03A is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy

Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus Renal Cell Carcinoma

March 10, 2022

By Support_Clique

Substudy 03B is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy

Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line Advanced Melanoma

March 10, 2022

By Support_Clique

Substudy 02B is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 Refractory Melanoma

March 10, 2022

By Support_Clique

Substudy 02A is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy

March 10, 2022

By Support_Clique

Substudy 02C is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Eficácia, segurança e tolerabilidade de V937 administrado por via intravenosa ou intratumoral com pembrolizumabe versus pembrolizumabe isoladamente em participantes com melanoma avançado/metastático

March 10, 2022

By Support_Clique

This is a Phase 2 study to assess the efficacy, safety, and tolerability of V937 administered both intratumorally (ITu) and intravenously (IV) as combination therapy with pembrolizumab (MK-3475) versus pembrolizumab alone

Segurança e eficácia de pembrolizumabe versus placebo como terapia adjuvante em participantes com carcinoma hepatocelular e resposta radiológica completa após ressecção cirúrgica ou ablação local

March 10, 2022

By clique_admin

This study will evaluate the safety and efficacy of pembrolizumab (MK-3475) versus placebo as adjuvant therapy in participants with hepatocellular carcinoma (HCC) and complete radiological response after surgical resection or local

Estudo de pembrolizumabe mais quimioterapia em participantes com adenocarcinoma gástrico ou da junção gastroesofágica (JGE)

March 10, 2022

By Support_Clique

The purpose of this study is to evaluate the efficacy of pembrolizumab (MK-3745) in combination with chemotherapy (Cisplatin combined with 5-Fluorouracil [FP regimen] or oxaliplatin combined with capecitabine [CAPOX regimen]) versus

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