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Study Keyword: Programmed Cell Death Ligand 1

El propósito de este estudio es evaluar la seguridad y la eficacia de pembrolizumab más quimioterapia con el estándar de atención (standard of care, SOC) (etopósido/platino [EP]) en participantes con cáncer de pulmón de células pequeñas en estadio extensivo (extensive stage small cell lung cancer, ES-SCLC) de diagnóstico reciente que no han recibido previamente terapia sistémica para esta neoplasia maligna.

Las hipótesis principales del estudio son que pembrolizumab + EP prolonga la supervivencia sin progresión (Progression-free Survival, PFS) según los criterios de evaluación de respuesta en tumores sólidos (Response Evaluation Criteria in Solid Tumors, RECIST) versión 1.1 mediante revisión central independiente a ciego (blinded independent central review, BICR) y supervivencia global (Overall Survival, OS) en comparación con placebo + EP en participantes adultos con ES-SCLC. En este estudio, RECIST 1.1 ha sido modificado para seguir un máximo de 10 lesiones objetivo y un máximo de 5 lesiones objetivo por órgano.

Con la enmienda 07 al protocolo (03-oct-2018), la medición de resultados del “Cambio desde el inicio en las semanas 12 y 24 en la Escala global de estado de salud/calidad de vida del Cuestionario de calidad de vida central 30 (Quality of Life Questionnaire Core 30, QLQ-C30) de la Organización Europea para la Investigación y el Tratamiento del Cáncer (European Organization for Research and Treatment of Cancer, EORTC)” se reemplazó con un análisis de un solo punto temporal en la semana 18.

Study Keyword: Programmed Cell Death Ligand 1

Estudio de pembrolizumab en combinación con etopósido/platino para participantes con cáncer de pulmón de células pequeñas en estadio extendido

April 22, 2022

By clique_admin

The purpose of this study is to assess the safety and efficacy of pembrolizumab plus standard of care (SOC) chemotherapy (etoposide/platinum [EP]) in participants with newly diagnosed extensive stage small cell

Estudio de seguridad y eficacia de pembrolizumab y quimioterapia en participantes con linfoma de Hodgkin clásico recién diagnosticado

March 10, 2022

By clique_admin

The purpose of this study is to evaluate the safety and efficacy of pembrolizumab (MK-3475) monotherapy, followed by chemotherapy, followed by pembrolizumab consolidation. The primary hypothesis of the study is that

Substudy 02D: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Melanoma Brain Metastasis

March 10, 2022

By Support_Clique

Substudy 02D is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus Renal Cell Carcinoma

March 10, 2022

By Support_Clique

Substudy 03B is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line Renal Cell Carcinoma

March 10, 2022

By Support_Clique

Substudy 03A is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy

Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line Advanced Melanoma

March 10, 2022

By Support_Clique

Substudy 02B is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 Refractory Melanoma

March 10, 2022

By Support_Clique

Substudy 02A is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy

March 10, 2022

By Support_Clique

Substudy 02C is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of

Eficacia, seguridad y tolerabilidad de V937 administrado por vía intravenosa o intratumoral con pembrolizumab frente a pembrolizumab solo en participantes con melanoma avanzado/metastásico

March 10, 2022

By Support_Clique

This is a Phase 2 study to assess the efficacy, safety, and tolerability of V937 administered both intratumorally (ITu) and intravenously (IV) as combination therapy with pembrolizumab (MK-3475) versus pembrolizumab alone

Seguridad y eficacia de pembrolizumab frente a placebo como terapia adyuvante en participantes con carcinoma hepatocelular y respuesta radiológica completa después de una resección quirúrgica o la ablación local

March 10, 2022

By clique_admin

This study will evaluate the safety and efficacy of pembrolizumab (MK-3475) versus placebo as adjuvant therapy in participants with hepatocellular carcinoma (HCC) and complete radiological response after surgical resection or local

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