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Condition: Head And Neck Squamous Cell Carcinoma

This is a study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) as a first line intervention in a PD-L1 selected population with participants with recurrent or metastatic head and neck squamous cell carcinoma.

Hypotheses include:

Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by blinded independent central review (BICR).
Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to Progression Free Survival (PFS) per RECIST 1.1 as assessed by BICR.
Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to overall survival (OS).

Condition: Head And Neck Squamous Cell Carcinoma

A Study of Pembrolizumab With or Without Lenvatinib as First Line Intervention in a Programmed Cell Death-ligand 1 Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

March 7, 2022

By clique_admin

This is a study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) as a first line intervention in a PD-L1 selected population with participants with recurrent or metastatic head and neck

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